PUBLICATIONS

2019 - Present

  1. Lengel, M., Dong, H., Rodriguez, K., Meier, K., Lehnert, N. “Nitric Oxide Reduction at a Single Iron Site Facilitated by Second Coordination Sphere Hydrogen Bonding via a Putative Fe(IV)-Oxo Intermediate” J. Am. Chem. Soc. 2026, 148, 1, 73-77.
  2. Lewis L. C., Badve P., Vaca, I. P., Ajmera, P., Lee, Y., Alexandrov, A., Meier K., Shafaat H. S., “A protein-based model of carbon monoxide dehydrogenase exhibits tunable covalency across cluster oxidation and ligand-bound states” Chem. Sci. 2026
  3. Edirisinghe, D. I. U., Dash, P., Yang, J., Moorkkannur, Narayanan, S., Neupane, D., Dissanayake, J. G. P. S., Eckhart, A., Meier K. K., Prabhakar, R., Makhlynets, O. “Phosphoester hydrolysis using a de novo designed protein: A combined experimental and computational study.” J. Inorg. Biochem. 2026, 113215.
  4. Kipouros, I., Lim, H., Appel, M.J., Meier, K.K., Hedman, B., Hodgson, K.O., Bertozzi, C.R., Solomon, E.I. “Mechanism of O2 Activation and Cysteine Oxidation by the Unusual Mononuclear Cu(I) Active Site of the Formylglycine-Generating Enzyme.” ACS Central Science. 2025 11 (5), 683-693.
  5. Rodriguez, K., Meier, K.K. “Defining Factors That Influence the Stability of Tetrameric EgtB from Chloracidobacterium Thermophilum: From pH Modulation to Affinity Tag Retention” Biochemistry. 2025, 64, 16, 3526-3534.
  6. Neupane, D.; Santos-Fernandez, M.; Fernandez-Lima, F.; Meier, K.K. “Multiple Copper Ions Bind to and Promote the Oligomerization of Huntingtin Protein with Non-pathological Repeat Expansions” Biochemistry. 2025, 64, 5, 1121-1135.
  7. Badve, P., Meier, K.K. “Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements That Influence Protein Dimerization.” Biochemistry. 2024, 63, 7, 926-938.
  8. Lobato, A.G., Ortiz-Vega, N., Zhu, Y., Neupane, D., Meier, K., Zhai, R.G. “Copper enhances aggregational toxicity of mutant huntingtin in a Drosophila model of Huntington’s disease.” Biochimica et Biophysica Acta (BBA) – Molecular Basis of Disease. 2024, 1870, 1, 166928.
  9. Lim, H.; Brueggemeyer, M.; Transue, W.; Meier, K.; Jones, S.; Kroll, T.; Sokaras, D.; Kelemen, B.; Hedman, B.; Hodgson, K.; Solomon, E. “Kβ X-ray Emission Spectroscopy of Cu(I)-Lytic Polysaccharide Monooxygenase: Direct Observation of the Frontier Molecular Orbital for H2O2 Activation” J. Am. Chem. Soc. 2023, 145, 29, 16015-16025.
  10. Paulino, V.; Mukhopadhyay, A.; Tsironi, I.; Liu, K.; Husainy, D.; Liu, C.; Meier, K.; Olivier, J.-H. “Molecular Engineering of Water-Soluble Oligomers to Elucidate Radical pi-Anion Interactions in n-Doped Nanoscale Objects.” J. Phys. Chem. C. 2021, 125, 19, 10526-10538.
  11. El Metwally A. E., Goodarzi, F., Meier, K. K., Zahran, E. M., Rayat, S., Kegnæs, S., Knecht, M. R., Bachas, L. G. “Cu2S@Bi2S3 Double-Shelled Hollow Cages as a Nanocatalyst with Substantial Activity in Peroxymonosulfate Activation for Atrazine Degradation” ACS Applied Nano Materials. 2021, 4, 11, 12222-12234.
  12. Jones, S.; Transue, W. J.; Meier, K. K.; Kelemen, B.; Solomon, E. “Kinetic analysis of amino acid radicals formed in H2O2-driven Cu(I) LPMO reoxidation implicates dominant homolytic reactivity.” Proc. Natl. Acad. Sci. USA. 2020, 117, 11916-11922.

Before U Miami

  1. Appel, M. J.*; Meier, K. K.*; Lafrance-Vanasse, J.; Lim, H.; Tsai, C.-L.; Tainer, J. A.; Solomon, E. I.; Bertozzi, C. R. “The formylglycine-generating enzyme binds substrate directly at a mononuclear Cu(I) center to initiate O2 activation” (*co-first authors) Proc. Natl. Acad. Sci. 2019, 116, 5370-5375. (Highlighted in: Schilter, D. Nature Reviews Chemistry 2019, 3, 203.)
  2. Meier, K.; Jones, S.; Kaper, T.; Hansson, H.; Koetsier, M.; Sarkehabadi, S.; Solomon, E.; Sandgren, M.; Keleman, B. “Oxygen activation by Cu LPMOs in recalcitrant carbohydrate polysaccharide conversion to monomer sugars.” Chem. Rev. 2018, 118, 2593-2635.
  3. Hansson, H.; Karkehabadi, S.; Mikkelsen, N.; Douglas, N.; Kim, S.; Lam, A.; Kaper, T.; Kelemen, B.; Meier, K. K.; Jones, S. M.; Solomon, E. I.; Sandgren, M. “A lytic polysaccharide monooxygenase from Hypocrea jecorina with a structurally defined linker sequence.” Biol. Chem. 2017, 292, 19099-19109.
  4. Meier, K. K.; Rogers, M.; Kovaleva, E. G.; Lipscomb, J. D.; Münck, E. Bominaar, E. “Enzyme Substrate Complex of the H200C Variant of Homoprotcatechuate 2,3-Dioxygenase: Mossbauer and Computational Studies.” Inorganic Chemistry. 2016, 55, 5862-5870.
  5. Meier, K. K.; Rogers, M.; Kovaleva, E. G.; Bominaar, E.; Lipscomb, J. D.; Münck, E. “A Long-Lived Fe(III)-(Hydroperoxo) Intermediate in the Active H200C Variant of Homoprotocatechuate 2,3-Dioxygenase: Characterization by Mossbauer, Electron Paramagnetic Resonance, and Density Functional Theory Methods.” Inorganic Chemistry. 2015, 54, 10269-10280.
  6. Prakash, J.; Rohde, G. T.; Meier, K. K.; Munck, E.; Que Jr., L. “Upside Down! Crystallographic and Spectroscopic Characterization of an [FeIV(Osyn)(TMC)]2+” Inorganic Chemistry. 2015, 54, 11055-11057.
  7. Serrano-Plana, J.; Oloo, W. N.; Acosta-Rueda, L.; Meier, K. K.; Verdejo, B.; Garcia-Espana, E.; Basallote, M. G.; Munck, E.; Que, Jr., L.; Company, A.; Costas, M. “Trapping a Highly Reactive Nonheme Iron Intermediate That Oxygenates Strong C-H Bonds with Stereoretention.” Am. Chem. Soc. 2015, 137, 15833-15842.
  8. Prakash, J.; Rohde, G. T.; Meier, K. K.; Jasniewski, A. J.; Van Heuvelen, K. M.; Munck, E.; Que, Jr., L. “Spectroscopic identification of an Fe(III) center, not Fe(IV), in the crystalline Sc-O-Fe adduct derived from [Fe(IV)(O)(TMC)]2+. Am. Chem. Soc. 2015, 137, 3478-3481.
  9. Biswas, A. N.; Puri, M. Meier, K. K.; Oloo, W. N.; Rohde, G. T.; Munck, E.; Que, Jr., L. “Modeling TauD-J: a high-spin nonheme oxoiron(IV) complex with high reactivity toward C-H bonds.” Am. Chem. Soc. 2015, 137, 2428-2431.
  10. Makris, T. M.; Vu, V. V.; Meier, K. K.; Komor, A. J.; Rivard, B. S.; Munck, E.; Que, Jr., L.; Lipscomb, J. D. “An Unusual Peroxo Intermediate of the Arylamine Oxygenase of the Chloramphenicol Biosynthetic Pathway.” J. Am. Chem. Soc. 2015, 136, 1608-1617.
  11. *Liu, J.; Meier, K.; Tian, S.; Zhang, J.; Guo, H.; Schulz, C. E.; Robinson, H.; Nilges, M. J.; Munck, E.; Lu, Y. “Redesigning an Electron Transfer Protein into a Mononuclear Non-heme Iron Enzyme: Preparation and Study of Fe(II)-M121E Azurin.” Am. Chem. Soc. 2014, 136, 12337-12344. *Co-first authors
  12. Chiang, C.-W.; Kleespies, S. T.; Stout, H. D.; Meier, K. K.; Li, P.-Y.; Bominaar, E. L.; Que, Jr., L.; Munck, E.; Lee, W.-Z. “Characterization of a Paramagnetic Mononuclear Nonheme Iron-Superoxo Complex.” Am. Chem. Soc. 2014, 136, 10846-10849.
  13. England, J.; Bigelow, J.O.; Van Heuvelen, K.M.; Farquhar, E.R.; Martinho, M.; Meier, K.K.; Frisch, J.R.; Munck, E.; Que, Jr., L. “An Ultra-Stable Oxoiron(IV) Complex and Its Blue Conjugate Base.” Sci. 2014, 5, 1204-1215.
  14. Oloo, W.N.; Meier, K.K., Munck, E., Que Jr., L. “Identification of a low-spin acylperoxoiron(III) intermediate in bio-inspired non-heme iron-catalysed oxidations.” Nature Commun. 2014, 5, 3046.
  15. Li, F.; Van Heuvelen, K.M.; Meier, K.K.; England, J.; Münck, E.; Que, Jr., L. “Sc3+ triggered oxoiron(IV) formation from O2 and its nonheme iron(II) precursor via a Sc3+-peroxo-Fe3+” J. Am. Chem. Soc. 2013, 135, 10198-10201.
  16. Banerjee, R.; Meier, K.; Münck, E.; Lipscomb, J.D. “Intermediate P* from Soluble Methane Monooxygenase Contains a Diferrous Cluster.” Biochemistry. 2013, 52, 4331-4342.
  17. Mbughuni, M.M.; Meier, K.K.; Münck, E.; Lipscomb, J.D. “Substrate-Mediated Oxygen Activation by Homoprotocatechuate 2,3-Dioxygenase: Intermediates Formed by a Tyrosine 257 Variant.”  Biochemistry.  2012, 51, 8743-8754.
  18. Cranswick, M.A.; Meier, K.K.; Shan, X.; Stubna, A.; Kaizer, J.; Mehn, M.P.; Münck, E.; Que, Jr., L. “Protonation of a Peroxodiiron(III) Complex and Conversion to a Diiron (III/IV) Intermediate: Implications to Proton-assisted O-O Bond Cleavage in Nonheme Diiron Enzymes.”  Inorganic Chemistry. 2012, 5, 10417-10426.
  19. Van Heuvelen, K.M.; Fiedler, A.T.; DeHont, R.; Shan, X.; Meier, K.K.; Bominaar, E.; Münck, E.; Que, Jr. L. “One-electron oxidation of an oxoiron(IV) complex to form an  [O=FeV=NR]+” Proc. Ntl. Acad. Sci. 2012, 109, 11933-11938.
  20. Mbughuni, M.M.; Chakrabarti, M.; Hayden, J.A.; Meier, K.K.; Dalluge, J.J.; Hendrich, M.P.; Münck, E.; Lipscomb, J.D. “Oxy-intermediates of homoprotocatechuate 2,3-dioxygenase: facile electron transfer between substrates.”  Biochemistry. 2011, 50, 10262-10274.
  21. Li, F.; Meier, K.K.; Cranswick, M.A.; Chakrabarti, M.; Van Heuvelen, K.M.; Münck, E.; Que, Jr., L. “Characterization of a High-Spin Non-Heme FeIII-OOH Intermediate and Its Quantitative Conversion to an FeIV=O Complex.” Am. Chem. Soc. 2011, 133, 7256-7259.
  22. Walsh, J.D.; Meier, K.; Ishima, R.; Gronenborn, A.M. “NMR Studies on Domain Diffusion and Alignment in Modular GB1 Repeats.” Biophysical Journal. 2010, 99, 2636-2646.

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